XlinkX/PD is a node in the commercially available Proteome Discover. For more information on how to acquire this platform and the XlinkX/PD nodes see the thermo website.
We receive a small fee for each XlinkX/PD license intended to cover development costs.
Adding the crosslink search to processing workflow is pretty straightforward. You can set up the workflow for a normal peptide search first. After follow these steps:
Likewise, you can extend the normal consensus workflow in the following manner:
Defining your own crosslinking reagent can be done in the Modifications tab in Proteome Discoverer.
This supports all linkers (incl. cleavable and non-cleavable).